The 2010 Durango-Durango Emakumeen Saria was the sixth running of the Durango-Durango Emakumeen Saria, a women's bicycle race held annually in Spain.

It took place on June 8, 2010, with Marianne Vos, Emma Johansson and Annemiek van Vleuten taking first, second and third place, respectively.

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