The 2010 Hamilton Tiger-Cats season was the 53rd season for the team in the Canadian Football League and their 61st overall.

The Tiger-Cats succeeded in making a second straight playoff appearance, as well as hosting a second straight playoff game, but lost the East Semi-Final to the Toronto Argonauts.

Running backs Wide receivers Slotbacks Defensive linemen Defensive backs Special teams Practice Roster Italics indicate Import player Roster updated 2010-08-09 Depth Chart • Transactions 47 Active, 8 Inactive, 6 PR → More rosters *-Team won in Overtime.