The 2010 Illinois State Redbirds football team represented Illinois State University as a member of the Missouri Valley Football Conference (MVFC) during the 2010 NCAA Division I FCS football season.

Led by second-year head coach Brock Spack, the Redbirds compiled an overall record of 6–5 with a mark of 4–4 in conference play, placing in a six-way tie for third in the MVFC.

Illinois State played home games at Hancock Stadium in Normal, Illinois.

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