The 2010 American Handball Championship, also called PanAmericano 2010, was the 14th official competition for senior men's national handball teams of North, Center, Caribbean and South America.

It was held from 22 to 26 June 2010 in Santiago, Chile.

It was also acting as the qualifying competition for the 2011 World Men's Handball Championship, securing three vacancies for the World Championship.

Brazil, Argentina and Chile got the Tickets for finishing at the first three places.

Argentina Chile (Host Nation) Uruguay Canada Brazil (Defending Champion) Cuba Greenland Dominican Republic All times are local (UTC−3).