2010 Pittsburgh Panthers football team

They were led by the sixth-year head coach Dave Wannstedt and played their home games at Heinz Field.

However, due to losses to both schools, Pitt did not earn the conference's bid to a Bowl Championship Series (BCS) game.

Senior safety Dom DeCicco has been named to the Jim Thorpe Award (defensive back) watch list.

Senior kicker Dan Hutchins was named to the Lou Groza Award (top placekicker) watch list.

Sports Illustrated ranked Pitt #16 in the annual College Football Preview issue on August 16, 2010.

With 7:11 left, Sunseri completed a 44-yard touchdown pass to Jon Baldwin, and a two-point conversion made it 24–21.

Tino Sunseri improved in his second career start, completing 24 of 34 passes for 275 yards, 2 touchdowns, and 1 interception.

Defensive end Greg Romeus sat out his second consecutive game due to injury, in hopes of returning against the Miami Hurricanes on September 23.

After UConn's Zach Frazer threw an interception on the first play of the game, the Panthers responded with a 4-yard touchdown run by Dion Lewis.

On the ensuing kickoff, UConn's Nick Williams returned the kick 95 yards for a touchdown to make the score 21–20 in favor of the Panthers at the end of the third quarter.

Todman gained 41 yards on the final drive, and UConn ran the remaining time off the clock to give the Panthers their first conference loss of the season.

[23] In the 10th edition of the River City Rivalry, the Panthers defeated the Cincinnati Bearcats 28–10 at Nippert Stadium.

The Panthers were led by sophomore running back Dion Lewis who rushed for a career-high 261 yards against Cincinnati, 6th most in a single game in Pitt history, and 4 touchdowns.

[24] With their win over Cincinnati, Pitt won a share of the Big East title along with West Virginia and Connecticut.

On December 7, 2010, Wannstedt resigned as head coach, reportedly under pressure following a disappointing 7–5 regular season and having failed to advance to a BCS bowl during his tenure.

[31] Ousted coach Dave Wannstedt defended his past "body of work" but acknowledged "an unfortunate stretch of incidents" the previous summer stating that "every player and each incident was evaluated on an individual basis" and that "we did our due diligence to make sure that we treated each player fair".