In addition to the graduation losses, quarterback Casey Turner, and offensive linemen Scott Schultz and Zac Zielinski, all backups, transferred out of UConn.

[7] Due to an NCAA ruling that states any USC junior or senior can transfer without sitting out for a year,[8] Shoemate was eligible to play in 2010.

Roster Archived May 19, 2011, at the Wayback Machine Recap: Connecticut opened the season on the road against the Michigan Wolverines in the first meeting between the two schools.

[31] Series: Michigan leads 1–0[30] Recap: Jordan Todman rushed for 151 yards on 15 carries and 3 touchdowns, all in the first half, as Connecticut dominated an overmatched Texas Southern team, 62–3.

[33] After the victory, game balls were awarded to Jordan Todman (offense), Lawrence Wilson (defense) and Anthony Sherman (special teams).

[34] Series: Connecticut leads 1–0[30] Recap: Jordan Todman rushed for a career-high 192 yards,[35] but had a costly fourth-quarter fumble that led to Temple's go-ahead touchdown as the Huskies lost to the Owls 30–16.

The Owls added a late field goal to make the final score 30–16.After the game, Todman was named to the Big East Conference's weekly honor roll.

The Huskies started the scoring early when Jerome Junior intercepted a pass by Bulls quarterback Jerry Davis for a touchdown.

Cody Endres, in his first game back from suspension, replaced UConn's starting quarterback, Zach Frazer, in the second half, and led the Huskies to two quick scores, including a 56-yard touchdown pass to Michael Smith.

Sio Moore, who was making his first career start, had 16 tackles and an interception, and was named the Big East Defensive Player of the Week.

It was Connecticut's second win ever against an opponent from the SEC.Wreh-Wilson, who also recovered a fumble in addition to his interception and touchdown, was named the Big East's Defensive Player of the Week.

Series: Tied 1–1[30] Recap:[42] Chas Dodd threw for 322 yards and led Rutgers to 10 fourth quarter points as the Scarlet Knights defeated UConn, 27–24.

During the week off, two starters were lost from the team when offensive guard, Erik Kuraczea withdrew from the university,[44] and quarterback, Cody Endres was suspended for the remainder of the season.

Their only venture into the red zone resulted in a missed field goal by Dave Teggart.It was the first time UConn was shut out since November 2005, when they lost at Pittsburgh, 24–0.

Series: Louisville leads 4–3[30] Recap:[47] Jordan Todman had a career-high 33 carries for 113 yards and a touchdown as UConn earned its first victory ever over West Virginia.

Despite being outgained, 414−278, the Huskies were beneficiaries of 4 Mountaineer lost fumbles, including one by Ryan Clarke in overtime.West Virginia scored first when wide receiver Brad Starks took an end-around handoff 53 yards for a touchdown just under 5 minutes into the game.

However, Zach Frazer, who started in place of an injured Mike Box, led them on a 12-play, 63-yard drive, culminating with a 39-yard field goal from Dave Teggart to end the first half.

Following a Huskies punt, West Virginia drove into UConn territory when Sio Moore forced Geno Smith to fumble.

UConn took the ball at West Virginia's 25-yard line, and Todman ran 4 times for 16 yards before Teggart kicked the game winning 27-yard field goal.

[49] Series: West Virginia leads 6−1[30] Recap:[50] Jordan Todman set new career highs with 222 yards rushing on 37 carries as the Huskies defeated Pittsburgh 30–28.

Dave Teggart added 2 field goals to give the Huskies a 13–7 lead in the third quarter.Later in the third quarter, Pittsburgh was able to get its offense going when Tino Sunseri completed a 42-yard pass to Jon Baldwin.

Although refuted by coach, Doug Marrone, there were some in the Syracuse organization who felt that UConn had run up the score on the Orange the previous year, possibly adding motivation to the game.

Later in the first half, following a Huskies interception by Kendall Reyes, Dave Teggart kicked a 35-yard field goal to make the score at half-time, 10–3.

After a couple of short runs by Delone Carter, Reyes sacked quarterback Ryan Nassib on the Orange 8-yard line, forcing him to fumble.

Following a Dave Teggart field goal to make the score 17–10, the Bearcats drove into the Huskies red zone with less than 2 minutes remaining in the first half.

[57] Series: Cincinnati leads 5–2[30] Recap:[29][58] The Huskies travelled to Tampa to conclude the regular season to take on the South Florida Bulls.

The teams traded punts for most of the remainder of the first half until South Florida's Jon Legiste intercepted a Zach Frazer pass at the Bulls seven-yard line.

[59] Dave Teggart, who successfully made 4 field goals in 4 attempts, including 2 of over 50 yards, was named the Big East Conference's Special Teams Player of the Week.

[60] Series: Tied 4–4[30] Shortly after the completion of the Fiesta Bowl, Jordan Todman announced that he would forgo his senior season and enter the NFL draft.

[62] Later that day, Maryland issued a press release stating that they had hired Edsall to replace Ralph Friedgen as head coach.