The 2010 Qatar motorcycle Grand Prix, officially the Commercialbank Grand Prix of Qatar, was the opening round of the 2010 MotoGP championship.

It took place on the weekend of 9–11 April 2010 at the Losail International Circuit located in Doha, Qatar.

Defending world champion Valentino Rossi won the opening MotoGP race after Casey Stoner crashed while in the lead, ending his undefeated streak from 2007.

All bikes in this class were powered with 600cc four-stroke engines based on the Honda CBR600RR.

Below are the standings for the top five riders and constructors after round one has concluded.