The 2010 Spanish motorcycle Grand Prix, officially the Gran Premio bwin de España, was the second round of the 2010 Grand Prix motorcycle racing season.

Jorge Lorenzo snatched a last-lap win in the MotoGP race to move top of the world championship standings.

[2] This event would be the last podium for Japanese Moto2 rider, Shoya Tomizawa; who finished in second place, before his death on 5 September 2010 at the San Marino Grand Prix.

The Moto2 race was red-flagged on the second lap after a fluid spill caused many riders to fall in the same turn.

The race was later restarted, with the distance shortened to 17 laps from the original 26.