The 2010 Novilon Eurocup Ronde van Drenthe was the 12th running of the Damesronde van Drenthe, a women's bicycle race in Drenthe, the Netherlands.

It was held on 11 April 2010 over a distance of 141.2 kilometres (87.7 miles).

It was rated by the UCI as a 1.1 category race.

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