The First Stage of the 2011 Copa Santander Libertadores de América football tournament ran from January 25 to February 3, 2011 (first legs: January 25–27; second legs: February 1–3).
The twelve teams were drawn into six ties on November 25, 2010, in Asunción.
[1] Teams played in two-legged ties on a home-away basis.
The following criteria were used for breaking ties on points:[2] The six winners advanced to the second stage to join the 26 automatic qualifiers.
Tied on points 3–3, Independiente won on goal difference.