The 2011 Copa Libertadores de América (officially the 2011 Copa Santander Libertadores de América for sponsorship reasons) was the 52nd edition of the Copa Libertadores de América, South America's premier international club football tournament organized by CONMEBOL.

Brazilian club Internacional were the defending champion, but they were eliminated by Uruguayan team Peñarol in the round of 16.

Internacional was succeeded by Brazilian club Santos, who won their third title after defeating Peñarol in the two-legged finals.

[2] Santos qualified to the 2011 FIFA Club World Cup and the 2012 Recopa Sudamericana.

Starting from 2011, the most recent Copa Sudamericana champion would earn a berth in the tournament.

Up until 2010, the 8 seeded teams included the reigning champion, and clubs from the football associations of Argentina and Brazil.

[6] All dates listed are Wednesdays, but matches may be played on the day before (Tuesdays) and after (Thursdays) as well.

The Second Stage, played in home-and-away round-robin format, began on February 9 and ended on April 20.

The last four stages of the tournament (round of 16, quarter-finals, semi-finals, and finals), played in home-and-away two-legged format, form a single-elimination tournament, contested by the sixteen teams which advance from the Second Stage.