The Amaury Sport Organisation and the governments of Argentina and Chile agreed to a return to South America for the event on 23 March 2010.

[1] The rally concluded in Buenos Aires, with Vladimir Chagin of Russia achieving a record seventh victory in the truck division, at the wheel of his Kamaz, thus becoming the most successful driver in a single category in the history of the event.

[4] 407 Teams started the race with 200 motorcycles and all-terrain vehicles, 140 cars, and 67 trucks on the podium across from the Obelisk, on the 9th of July Avenue; one of Buenos Aires' major boulevards.

[3] Despres, a three-time winner himself, won stage eleven but ended the rally fifteen minutes behind Coma in second place.

However, on the final stage, López suffered a mechanical failure 22 kilometres (14 mi) from the finish line and lost over an hour to his rivals.