2011 Regional League Division 2 North-East Region is the 3rd season of the League competition since its establishment in 2009.
It is in the third tier of the Thai football league system.
Buriram were promoted to the 2011 Thai Division 1 League after winning the 2010 Regional League Division 2 championship pool.
Amnat Charoen Town joined the newly expanded league setup.
Ubon United are in the second year of their two-year ban.