Barcelona dominated the match, winning 3–1 with goals from Pedro, Lionel Messi and David Villa, securing their fourth Champions League title.
However, in 2008, United defeated Barcelona 1–0 on aggregate, at the semi-final stage, en route to claiming their third trophy.
The 1968 and 1978 finals were both won by English sides: Manchester United beat Benfica 4–1 in 1968 and Liverpool defeated Club Brugge 1–0 in 1978.
Benfica also lost in the 1963 final, beaten 2–1 by A.C. Milan, while Ajax won the first of three consecutive European Cups at Wembley in 1971, beating Panathinaikos 2–0.
That year, it hosted its first FA Cup Final, when almost 200,000 spectators attempted to watch the match between Bolton Wanderers and West Ham United.
Wembley played host to all of England's matches at the 1966 FIFA World Cup, including the 4–2 victory over West Germany in the final, and at UEFA Euro 1996.
Hosted by Sky Sports presenter Richard Keys, the event was also attended by UEFA competitions director Giorgio Marchetti, former British Minister for Sport and representative of the City of London Kate Hoey, General Secretary of The Football Association Alex Horne, and England Women's international Faye White.
The logo for the final is in the style of a heraldic crest and features the European Champion Clubs' Cup in the centre, flanked by two lions.
According to the designers of the logo, London-based Radiant Studios, the lions are intended to represent the two teams that would contest the final, battling over the trophy.
The application period for the latter opened on 24 February 2011 and closed at 17:00 GMT on 18 March, with recipients to be determined by a random ballot before 6 April.
The event was also used to promote the start of ticket sales, and was attended by final ambassador Gary Lineker, his women's final counterpart Hope Powell, UEFA Champions Festival ambassador Graeme Le Saux, UEFA fourth vice-president Marios N. Lefkaritis, and vice-chairman of The Football Association Barry Bright.
Revealed on 3 March 2011 at Wembley Stadium, the Adidas Finale London features the "Starball" design synonymous with the UEFA Champions League.
The festival ran for the entire week leading up to the show-piece match at Wembley, closing a few hours before kick-off.
Among the attractions at the festival were displays detailing the history of the European Cup, miniature football pitches for use by the public, and the trophy itself.
[28] United's game plan was to get bodies in front of Barcelona's attack and hope to keep the ball away from their end whenever they received possession.
Messi almost gave Barcelona the lead in the 52nd minute when he latched onto a rebound from a Van der Sar save from Dani Alves, but Patrice Evra cleared off the line with his head.
Messi turned Rio Ferdinand and got a shot away from about eight yards out, forcing a save from Van der Sar.
In a gesture by his teammates, Eric Abidal, who had undergone surgery only two months earlier to remove a tumour in his liver, was given the honour of wearing the captain's armband during the trophy presentation ceremony.
[34] Meanwhile, Manchester United manager Sir Alex Ferguson acknowledged that the Barcelona side was the best team he had ever faced.
[37] The match was the last for Manchester United goalkeeper Edwin van der Sar, who had announced his retirement from football to follow the 2011 season.
[42] The match was broadcast live in 3D in the Trädgår'n club hall in Gothenburg, Sweden on the Guinness Book of World Records' largest television.