The fifty-fourth edition of the Caribbean Series (Serie del Caribe) baseball competition was played in 2012.
It was held from February 2 through to February 7 with the champions teams from Dominican Republic (Leones del Escogido), Puerto Rico (Indios de Mayagüez), Venezuela (Tigres de Aragua), and Mexico (Yaquis de Obregón).
The format consisted of twelve games in a double round-robin format with each team facing each other twice.
The games were played at Estadio Quisqueya in Santo Domingo, Dominican Republic.
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