The 2012 John Newcombe Women's Pro Challenge was a professional tennis tournament played on outdoor hard courts.

It was the first edition of the tournament which was part of the 2012 ITF Women's Circuit.

It took place in New Braunfels, Texas, United States, on 29 October–4 November 2012.

The following players received wildcards into the singles main draw: The following players received entry from the qualifying draw: The following players received entry as Lucky Losers: