The Chiefs went 0–12 against AFC opponents in 2012; their only wins of the season were from NFC teams, against the Carolina Panthers and New Orleans Saints.

[1] On December 1, 2012, the day before the Chiefs' week 13 game against the Carolina Panthers, linebacker Jovan Belcher murdered his girlfriend then drove to Arrowhead Stadium where he killed himself in front of Crennel and general manager Scott Pioli.

The Chiefs held a moment of silence for domestic violence victims and the teams met for a prayer on the field prior to the game.

The Chiefs had the number 1 pick in the 2013 National Football League Draft based on strength of schedule.

The Chiefs did defeat the Saints in week 3, but didn't lead until their game winning field goal in overtime.

The Chiefs broke the streak in Week 10 against the Pittsburgh Steelers when they led 10–0 in the second quarter before losing the game 16–13 in overtime.

[6] Chiefs tackle Eric Winston claimed Kansas City hometown fans cheered the injury of quarterback Matt Cassel in a Week 5 loss to the Baltimore Ravens calling it "Sick", however fans claim it was because Brady Quinn was seen coming onto the field and were cheering for him.

"[9] When asked why running back Jamaal Charles carried the ball only 5 times in a week 8 loss to the Oakland Raiders, Romeo Crennel responded "Now, that I'm not exactly sure, either.

[11] In Week 16, the team rushed for a franchise record of 352 yards against the Colts and still lost the game.

They were 23rd in total offense, 32nd in points scored,[13] and 37 giveaways, tied for worst in the NFL.

Directly dupliplcating their 2008 record for the worst in franchise history while tying the 1981 Colts with their 9th 14+ loss.