After a surprising 4–0 start, which included a major upset of the New England Patriots in week 2, the Cardinals lost 11 of their final 12 games, and missed the playoffs for a third consecutive season, resulting in the firing of head coach Ken Whisenhunt after six seasons.

Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams Reserve at University of Phoenix Stadium, Glendale, Arizona The Cardinals began their season at home against their divisional rival Seahawks with quarterback John Skelton at the starting helm.

In a game most remebered as possilbly the worst QB duel in NFL history the Cardinals fell 7-6 marking their 8th straight loss.

at University of Phoenix Stadium, Glendale, Arizona With this win the Cardinals ended their 9 game losing streak.

at University of Phoenix Stadium, Glendale, Arizona at Candlestick Park, San Francisco, California With this loss, the Cardinals surpassed the 1989 Chicago Bears for the worst record by an NFL team starting 4–0.