The qualifying rounds of the 2013 CAF Champions League were played from 15 February to 5 May 2013, to decide the eight teams which advanced to the group stage.
[2] The following 56 teams were entered into the draw: Qualification ties were played on a home-and-away two-legged basis.
Note: Al-Ittihad played their home match in Morocco due to security concerns in Libya.
Enugu Rangers advanced to the first round after Sporting Clube do Príncipe failed to show up for the first leg.
Primeiro de Agosto won 4–3 on aggregate and advanced to the first round.
Coton Sport won the penalty shoot-out and advanced to the first round.
ASFA Yennenga won the penalty shoot-out and advanced to the first round.
JSM Béjaïa won on the away goals rule and advanced to the second round.
AC Léopards won on the away goals rule and advanced to the second round.
The winners of each tie advanced to the group stage, while the losers entered the Confederation Cup play-off round.
Orlando Pirates won 3–2 on aggregate and advanced to the group stage.
Recreativo do Libolo won 3–1 on aggregate and advanced to the group stage.
Espérance de Tunis won 1–0 on aggregate and advanced to the group stage.
Séwé Sport won on the away goals rule and advanced to the group stage.
AC Léopards won the penalty shoot-out and advanced to the group stage.