The second stage of the 2013 Copa Libertadores de América was played from February 12 to April 18, 2013.
[1] The draw of the tournament was held on December 21, 2012, 11:00 UTC−3, at the CONMEBOL Convention Centre in Luque, Paraguay.
The seeding of each team was determined by their association and qualifying berth (as per the rotational agreement established by CONMEBOL, the teams which qualified through berths 1 from Colombia, Ecuador, Peru and Venezuela were seeded into Pot 1 for odd-numbered years, while the teams which qualified through berths 1 from Bolivia, Chile, Paraguay and Uruguay were seeded into Pot 1 for even-numbered years).
However, a first stage winner, whose identity was not known at the time of the draw, could be drawn into the same group with another team from the same association.
[1] The matches were played on February 12–14, 19–21, 26–28, March 5–7, 12–14, April 2–4, 9–11, and 16–18, 2013.