The knockout stages of the 2013 Copa Libertadores de América were played from April 24 to July 24, 2013.
Tied 2–2 on aggregate, Santa Fe won on away goals.
Tied 0–0 on aggregate, Newell's Old Boys won on penalties.
The finals were played on a home-and-away two-legged basis, with the higher-seeded team hosting the second leg.
The teams tied on aggregate, the away goals rule was not used, and 30 minutes of extra time were played.