Game 2 was a back-and-forth affair that ended on a Kolten Wong walk-off home run in the ninth inning to give the Cardinals a 5–4 win.

The Giants cut the lead in half when Joaquín Árias pinch-hit for Peavy in the top of the fifth and scored Brandon Belt on an RBI groundout.

The Giants took the lead in the top of the seventh on an RBI single from Gregor Blanco off Cardinals reliever Carlos Martínez.

The Cardinals tied it back up in the bottom of the seventh on a pinch-hit home run from Oscar Taveras off Jean Machi.

After Blanco lined out, Joe Panik worked a walk, with ball four coming on a wild pitch that allowed Duffy to score the tying run from second base.

Travis Ishikawa hit a deep drive to right-center that was nearly a grand slam but was blown back towards the outfield due to a strong wind blowing in from right field.

As the bullpens took over, the game remained tied until the bottom of the tenth inning when Choate issued a leadoff walk to Crawford and a single to Juan Pérez.

After Gregor Blanco attempted to bunt the runners over, Choate threw wildly to first base, allowing Crawford to score the winning run.

The Cardinals struck first in the top of the first on Matt Adams's RBI single off of Ryan Vogelsong with two on, but the Giants tied the game in the bottom of the inning on Buster Posey's sacrifice fly off of Shelby Miller with runners on first and third.

In the third with runners on first and third with no outs, Jhonny Peralta's double play scored Matt Holliday before Wong's home run made it 4–1 Cardinals.

In the bottom of the sixth, with runners on second and third with one out off of Marco Gonzales, Gregor Blanco's fielder's choice and Joe Panik's groundout scored a run each, then Posey's RBI single off of Seth Maness gave the Giants a 6–4 lead.

[12] The Giants' lead didn't last long, as Bumgarner gave up home runs to Matt Adams and Tony Cruz in the top of the fourth.

In the top of the ninth, Santiago Casilla gave up a single and two walks, leading manager Bruce Bochy to bring in Jeremy Affeldt, who retired Oscar Taveras (in what would be his final at-bat before his death 10 days later in a car accident) to escape the jam.

In the bottom of the ninth, the Cardinals brought in Michael Wacha, who put two runners on before giving up a 3-run walk-off home run to Travis Ishikawa that clinched the pennant for the Giants, sending San Francisco to its third World Series appearance in five seasons.

Bumgarner would be the seventh player to win a LCS and World Series MVP in the same postseason, and just the fourth pitcher, joining the Orel Hershiser in 1988, Livan Hernandez in 1997, and Cole Hamels in 2008.

In 2016, the Giants made the playoffs again as a wildcard, but lost to the eventual World Champion Cubs in the National League Division Series.