The 2015–16 Eastern Illinois Panthers men's basketball team represented Eastern Illinois University during the 2015–16 NCAA Division I men's basketball season.

The Panthers, led by fourth-year head coach Jay Spoonhour, played their home games at Lantz Arena and were members of the West division of the Ohio Valley Conference.

They lost in the first round of the OVC tournament to Murray State.

The Panthers finished the 2014–15 season 18–15, 9–7 in OVC play, to finish in third place in the West division.

They advanced to the quarterfinals of the OVC tournament where they lost to Belmont.