The 2015 season was the Buffalo Bills' 46th in the National Football League (NFL), their 56th overall, their third under the leadership of general manager Doug Whaley and their first under head coach Rex Ryan.

It was also their first full season under the ownership of Terry and Kim Pegula (who also own the Buffalo Sabres), having purchased the Bills partway through 2014 after the death of longtime owner Ralph Wilson that March at the age of 95.

The Bills began their season with an open competition for the starting quarterback position after Kyle Orton, the starter for most of the 2014 campaign, retired during the offseason, so the team acquired free agent Tyrod Taylor, a former backup quarterback of the Baltimore Ravens, who won the competition over incumbent second-string quarterback EJ Manuel and trade acquisition Matt Cassel, the latter of whom the team later traded along with a seventh-round pick in 2017 to the Dallas Cowboys, in exchange for a fifth-round draft pick in 2017.

This made Cassel the starting quarterback of record, although it his only play of the game and he did not attempt either a pass or run.

Sadly, with the stunning loss, the Bills dropped to 3-4 heading into the bye week, marking the first time they had been under .500 all season.

This was the debut for NFL Color Rush uniforms, with the Bills in all red and the Jets in all kelly green.

McCoy was seen kissing the Eagles logo, but did not stick around to interact with his former teammates or coach Chip Kelly.

Prior to the game, the team called for paid volunteers to help shovel snow out of Ralph Wilson Stadium.

[6] Former Bills quarterback Ryan Fitzpatrick made his first return to Buffalo since being cut after the 2012 season, hoping to clinch a playoff spot for his new team with a win.

Despite the Jets setting various team records, the Bills ultimately pulled out a win to close the season at 8-8 for the first time since 2002 in their final regular season game before Ralph Wilson Stadium was renamed New Era Field the following summer, not only keeping the Jets out of the playoffs for a fifth straight year, but helping the Pittsburgh Steelers reach the playoffs.