The 2015 Colorado Buffaloes football team represented the University of Colorado at Boulder during the 2015 NCAA Division I FBS football season.

Led by third-year head coach Mike MacIntyre, the Buffaloes played their home games on-campus at Folsom Field in Boulder and were members of the South Division of the Pac-12 Conference.

They finished the season 4–9, 1–8 in Pac-12 play to finish in last place in the South Division.

Conference opponents not played this season: California, Washington