The 2015 McNeese State Cowboys football team represented McNeese State University as a member of the Southland Conference during the 2015 NCAA Division I FCS football season.

Led by Matt Viator in his tenth and final season as head coach, the Cowboys compiled an overall record of 10–1 with a mark of 9–0 in conference play, winning the Southland title.

McNeese State received the conference's automatic bid to NCAA Division I Football Championship playoffs, where, after a first-round bye, the Cowboys lost in the second round to fellow Southland member, Sam Houston State.

The team played home games at Cowboy Stadium in Lake Charles, Louisiana.

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