The 2022 Southeastern Louisiana Lions football team represented Southeastern Louisiana University as a member of the Southland Conference during the 2022 NCAA Division I FCS football season.

The Lions played their home games at Strawberry Stadium in Hammond, Louisiana.

The Southland Conference released their preseason poll on July 20, 2022.

[1] The Southland Conference announced the 2022 preseason all-conference football team selections on July 13, 2022.

Roster Southeastern Louisiana Lions finalized their 2022 schedule on February 11, 2022.