Lazio competed in Serie A, finishing fifth, and in the Coppa Italia, where they finished as runners-up to Juventus, losing the final 2–0.

Following the extremely brief tenure of Marcelo Bielsa during pre-season, Simone Inzaghi, who had acted as interim coach following Stefano Pioli's sacking in the second half of the 2015–16 season, assumed the post permanently.

New signing Ciro Immobile finished as the club's top scorer with 23 goals in Serie A and 26 in total.

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