Two-time defending champion Novak Djokovic defeated Milos Raonic in the final, 6–2, 6–0 to win the men's singles tennis title at the 2016 Indian Wells Masters.

It was his then-record-breaking fifth Indian Wells title, before Roger Federer tied the record the following year.

All seeds receive a bye into the second round.

Click on the seed number of a player to go to their draw section.