[1] Eric Hosmer, an infielder for the Kansas City Royals, was named the 2016 All-Star Game Most Valuable Player.

Former commissioner Bud Selig said that Baltimore was a prime candidate to host the event, but the Padres ended up with the game.

In the bottom of the second inning, the AL got to Johnny Cueto when Eric Hosmer homered to left to tie the game.

In the bottom of the third, after walking, David Ortiz was replaced by Edwin Encarnación and left the field to a standing ovation in his final all-star game.

The NL shrunk the lead with an RBI single by Marcell Ozuna in the top of the fourth off Aaron Sanchez.

In the top of the eighth, the NL loaded the bases, but could not capitalize when Aledmys Díaz struck out looking against Will Harris to end the frame.

In the ninth, Zach Britton got Nolan Arenado to ground into a double play to secure the 4–2 victory for the American League.