Rafael Nadal defeated Gaël Monfils in the final, 7–5, 5–7, 6–0 to win the singles tennis title at the 2016 Monte-Carlo Masters.

It was his record-extending ninth Monte-Carlo Masters title.

Novak Djokovic was the defending champion, but lost in the second round to Jiří Veselý.

The top eight seeds receive a bye into the second round.

Click on the seed number of a player to go to their draw section.