The 2016 Open de Nice Côte d'Azur was a men's tennis tournament played on outdoor clay courts.

It was the 32nd and final edition of the Open de Nice Côte d'Azur and part of the ATP World Tour 250 series of the 2016 ATP World Tour.

The tournament was replaced on the ATP World Tour by the Lyon Open.

First-seeded Dominic Thiem won the singles title.

The following players received wildcards into the singles main draw: The following player received entry using a protected ranking: The following players received entry from the qualifying draw: The following pairs received wildcards into the doubles main draw: The following pair received entry as alternates: