The Cougars, led by twenty-eighth year head coach Sandy Montgomery, played their home games at Cougar Field on the SIUE campus as a member of the Ohio Valley Conference (OVC).

They were joined by six freshmen and three transfer students,[3] It was announced in the fall that the 2015 OVC Pitcher-of-the-Year Haley Chambers had left school for personal reasons.

[5] The Cougars opened the season with their usual extended on-the-road schedule.

were cancelled due to weather; with a win versus UIC and a loss to Bradley.

In OVC play, SIUE went 15–11 (one game against Eastern Kentucky cancelled by thunderstorms) to finish in fourth place.