The 2016 South Carolina State Bulldogs football team represented South Carolina State University in the 2016 NCAA Division I FCS football season.

They were led by 15th-year head coach Oliver Pough and played their home games at Oliver C. Dawson Stadium.

They were a member of the Mid-Eastern Athletic Conference (MEAC).

[1] They finished the season 5–6, 5–3 in MEAC play to finish in a two way tie for third place.