Daniel Ricciardo slotted into second while Hamilton's teammate and closest championship rival Nico Rosberg fell back to third.
On the corner before the backstraight DRS zone, Esteban Gutiérrez of the Haas F1 Team locked up the front right tyre heavily and retired subsequently due to brake problems.
On lap 31, Max Verstappen retired due to a gearbox problem and stopped out of the first DRS zone, triggering a Virtual Safety Car period.
Hamilton went on to win his 5th race in the United States, with Nico Rosberg in second and Daniel Ricciardo rounding out the podium spots.
Hamilton reduced Rosberg's lead in the Drivers' Championship to 26 points with 3 races left in the season.