[6] The race marked the forty-seventh running of the United States Grand Prix, the thirty-ninth time that the race was run as a World Championship event since the inaugural season in 1950, and the sixth time that a World Championship round was held at the Circuit of the Americas in Austin, Texas.

Mercedes clinched its fourth successive World Constructors' Championship after Hamilton won and Bottas finished 5th.

Carlos Sainz Jr. moved from Toro Rosso to Renault and replaced Jolyon Palmer.

[7] Daniil Kvyat returned to Toro Rosso after having missed the Malaysian and Japanese Grands Prix, taking over Sainz's car.

The purple branding on the ultra-soft compound was replaced by pink for the race to raise awareness of breast cancer.