[6] In the quarter-final they drew fellow Premier League team West Ham United at Old Trafford, where they progressed 4–1 due to two goals each from Zlatan Ibrahimović and Anthony Martial despite manager José Mourinho serving a touchline ban.

[17] Manolo Gabbiadini had the ball in the net early in the game after a low cross from the right by Cédric, but the goal was controversially disallowed for offside.

[18][19] Zlatan Ibrahimović opened the scoring in the 19th minute, with a free kick to the left of Southampton goalkeeper Fraser Forster awarded following a foul by Oriol Romeu on Ander Herrera.

[18] Despite the Saints enjoying a spell of pressure on the United goal, Jesse Lingard doubled the lead in the 38th minute with a low right foot shot to the right corner of the net from just inside the penalty area.

[18] Gabbiadini brought Southampton back into the game on the stroke of half-time, converting James Ward-Prowse's cross from the right from three yards out.

[18] The Saints continued having chances to take the lead throughout the second half, as Dušan Tadić and Ward-Prowse saw efforts saved by United goalkeeper David de Gea, and Oriol Romeu hit the post with a header from a corner, but with three minutes remaining Ibrahimović scored his second with a close range header after a cross from Ander Herrera on the right.