The 2017 season was Santa Cruz's 104th season in the club's history.

Santa Cruz competed in the Campeonato Pernambucano, Copa do Brasil, Copa do Nordeste[6] and Série B.

[7] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.

Source: Santa Cruz official website (c) Indicates the caretaker manager