The 2018–19 East Carolina Pirates women's basketball team represented East Carolina University during the 2018–19 NCAA Division I women's basketball season.

The Pirates, led by first year head coach Chad Killinger and later first year head coach Nicole Mealing, played their home games at Williams Arena at Minges Coliseum and were fifth year members of the American Athletic Conference.

They defeated SMU in the first round before losing in the quarterfinals of the American Athletic women's tournament to Connecticut.

Assistant coach Killinger was initially named interim head coach of the Pirates for the season, but health concerns led to his resignation 11 games into the season on December 26, 2018, and Killinger's top assistant Mealing was named interim coach for the rest of the season.

Audio broadcasts for most road games can also be found on the opponents website.