The 2018–19 Southeastern Louisiana Lions basketball team represented Southeastern Louisiana University during the 2018–19 NCAA Division I men's basketball season.

The Lions were led by fifth-year head coach Jay Ladner, and played their home games at the University Center in Hammond, Louisiana as members of the Southland Conference.

3 seed in the Southland tournament, they advanced to the semifinals, where they lost to Abilene Christian.

The Lions finished the 2017–18 season 22–12, 15–3 in Southland play to finish in a tie for the Southland regular season championship with Nicholls State.

1 seed in the Southland tournament, they defeated Sam Houston State in the semifinals before losing in the championship game to Stephen F. Austin.