The 2018–19 Southern Jaguars basketball team represented Southern University during the 2018–19 NCAA Division I men's basketball season.

The Jaguars, led by head coach Sean Woods, played their home games at the F. G. Clark Center in Baton Rouge, Louisiana as members of the Southwestern Athletic Conference.

Due to Grambling State's Academic Progress Rate violations and subsequent postseason ineligibility, the Jaguars received the No.

They defeated Jackson State in the quarterfinals before losing to Arkansas–Pine Bluff in the semifinals.

On April 12, 2018, Southern hired Stetson assistant coach and former Morehead State/Mississippi Valley State head coach Sean Woods for the full-time job.