The 2021–22 Southern Jaguars basketball team represented Southern University in the 2021–22 NCAA Division I men's basketball season.

The Jaguars, led by fourth-year head coach Sean Woods, played their home games at the F. G. Clark Center in Baton Rouge, Louisiana as members of the Southwestern Athletic Conference.

The Jaguars finished the 2020–21 season 8–11 overall, 8–6 in SWAC play, to finish in 5th place.

In the SWAC tournament, they were defeated by Grambling State in the quarterfinals.

[1] Roster Last update: January 4, 2022 Source[2]