The 2018–19 season was Unione Calcio Sampdoria's 62nd season in Serie A, and their 7th consecutive season in the top-flight.

The club competed in Serie A and in the Coppa Italia.

The season was the third in charge for coach Marco Giampaolo.

Last updated: 26 May 2019.

Source: Competitive matches Last updated: 26 May 2019Source: Competitions