Espérance de Tunis won the title for the third time, defeating Al Ahly in the final, and qualified as the CAF representative at the 2018 FIFA Club World Cup in the United Arab Emirates, and also earned the right to play against the winners of the 2018 CAF Confederation Cup, Raja Casablanca, in the 2019 CAF Super Cup.

[2] Wydad AC were the defending champions, but were eliminated in the quarter-finals by ES Sétif.

[2] As a result, theoretically a maximum of 68 teams could enter the tournament – although this level has never been reached.

The draw for the group stage was held on 21 March 2018, 19:00 EET (UTC+2), at the Ritz Carlton in Cairo, Egypt.

[2] The bracket was decided after the draw for the knockout stage (quarter-finals and semi-finals), which was held on 3 September 2018, 20:00 EET (UTC+2), at the CAF headquarters in Cairo, Egypt.

[18] In the semi-finals, the four quarter-final winners played in two ties, with the matchups and order of legs decided by draw.