The 2018 CAF Confederation Cup knockout stage was played from 16 September to 2 December 2018.
[1] A total of eight teams competed in the knockout stage to decide the champions of the 2018 CAF Confederation Cup.
If the aggregate score was tied after the second leg, the away goals rule would be applied, and if still tied, extra time would not be played, and the penalty shoot-out would be used to determine the winner (Regulations III.
[3] The bracket of the knockout stage was determined as follows:[2] The bracket was decided after the draw for the knockout stage (quarter-finals and semi-finals), which was held on 3 September 2018, 19:00 EET (UTC+2), at the CAF headquarters in Cairo, Egypt.
In the semi-finals, the four quarter-final winners played in two ties, with the matchups and order of legs decided by draw.