Raja Casablanca won the title for the first time, defeating AS Vita Club in the final, and earned the right to play against the winners of the 2018 CAF Champions League in the 2019 CAF Super Cup.

A further 16 teams eliminated from the 2018 CAF Champions League entered the play-off round.

The draw for the play-off round was held on 21 March 2018, 19:00 EET (UTC+2), at the Ritz Carlton in Cairo, Egypt.

The draw for the group stage was held on 21 April 2018, 14:00 EET (UTC+2), at the CAF headquarters in Cairo, Egypt.

[18][19] The 16 teams, all winners of the play-off round of qualifying, were drawn into four groups of four.

[2] The bracket was decided after the draw for the knockout stage (quarter-finals and semi-finals), which was held on 3 September 2018, 19:00 EET (UTC+2), at the CAF headquarters in Cairo, Egypt.

[22] In the semi-finals, the four quarter-final winners played in two ties, with the matchups and order of legs decided by draw.