The 2018 Ecuador Open Quito was an ATP men's tennis tournament played on outdoor clay courts.

It was the 4th edition of the Ecuador Open Quito as part of the ATP World Tour 250 series of the 2018 ATP World Tour.

It took place in Quito, Ecuador from 5 February through 11 February 2018.

Unseeded Roberto Carballés Baena, who entered the main draw as a qualifier, won the singles title.

The following players received wildcards into the singles main draw: The following players received entry using a protected ranking: The following players received entry from the qualifying draw: The following player received entry as a lucky loser: The following pairs received wildcards into the doubles main draw: The following pairs received entry as alternates: