The Cyclones hosted Big 12 foes Oklahoma, West Virginia, Texas Tech, Baylor, and Kansas State and travel to TCU, Oklahoma State, Kansas, and Texas.

For their non-conference schedule the Cyclones hosted Drake and Akron as well as traveling to in–state rival Iowa.

Quarterback Running back Wide receiver Placekicker Tight end Offensive lineman Defensive lineman Linebacker Defensive back Long snappers Punter at Kinnick Stadium, Iowa City, IA

Iowa State's Freshman Brock Purdy replaced Zeb Noland at quarterback and passed 18-for-23 for 318 yards and produced four touchdowns.

At the beginning of the second half, Baylor's Chris Miller got a flag for a late hit against Iowa State running back David Montgomery, pushing him into a Gatorade cooler, escalating tensions.

After a slow start, Kansas State held a solid lead for most of the game.

Kansas State had racked up a 17 point lead with only 12 minutes remaining in the game.

From there, Iowa State's Mike Rose grabbed a loose ball for a touchdown and the Cyclones controlled the game to rally with 21 unanswered points.

The Cyclones were scheduled to take on the Incarnate Word Cardinals as a replacement for their cancelled South Dakota State game from Week 1, however, the Cardinals qualified for the FCS Playoffs, requiring a different opponent.