The 2018 Louisville City FC season was the club's fourth season in Louisville, Kentucky playing in the United Soccer League, which as of 2018 is the second-tier league in the United States soccer league system.

The club began their pre-season campaign on February 24 before the league commenced on March 17.

They also competed in the U.S. Open Cup entering in the second round.

They entered the season as the reigning USL Cup champions and became the first team in USL history to successfully defend their title.

Source: Match reports Louisville City entered the 2018 U.S. Open Cup with the rest of the United Soccer League in the second round.