The host city was announced on April 6, 2015, by Major League Baseball Commissioner Rob Manfred;[1] it was the fifth All-Star Game in Washington, D.C., and the first since 1969, when the second Washington Senators hosted.

It was also the first time that the Nationals had hosted the All-Star Game, and the first time that the Nationals franchise had hosted it since 1982, when the franchise played as the Montreal Expos.

For the second straight year, the Houston Astros led both the American League and all of baseball in sending six All-Stars to the game.

For the fourth year, voting was conducted online exclusively.

[6] The winners of the All-Star Final Vote were Jean Segura of the American League's Seattle Mariners and Jesús Aguilar of the National League's Milwaukee Brewers.